Art of Murder: FBI Confidential is a 3rd person, point and click adventure game. As the title suggests, the game follows FBI investigator, Nicole Bonnet, who is trying to discover the identity of the killer behind a series of ritual murders of wealthy New Yorkers. The victims are tortured and their hearts are removed by a mysterious weapon. The murders will take Nicole from New York City to the ancient Incan civilization in Peru. Hopefully Nicole will discover the murderer before she ends up the next victim.

Puzzles are based on collecting and analyzing clues, such as fingerprinting and using luminol to locate bloodstains. Nicole will encounter many individuals and have numerous conversations, but few puzzles are conversation based. In addition, there are a number of puzzles that are based on trial and error.